The Global Aptamers Market in terms of revenue was estimated to be worth $151 million in 2021 and is poised to reach $342 million by 2026, growing at a CAGR of 17.7% from 2021 to 2026. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. Growth of the market is attributed to factors such as increase in number of clinical trials for development of aptamer-based therapeutics, increase in awareness about advantages of aptamers as compared to antibodies, rising investment in pharmaceutical R&D, and rising prevalence of chronic and rare diseases to increase the demand for aptamer-based therapeutics and diagnostics. Growth in the venture capital funding for research on aptamers and growing collaborations with research institutes and pharmaceutical companies are also expected to offer a wide range of growth opportunities to players in the market. On the other hand, low market acceptance as compared to antibodies is likely to restrain the market growth while shortage of skilled & trained professionals may challenge market growth to a certain extent.
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Key Market Players:
Some of the key players operating in the aptamers market include Aptamer Group (UK), Raptamer Discovery Group (US), SomaLogic Inc., (US), Aptamer Sciences, Inc. (South Korea), Aptagen, LLC (US), Maravai Lifesciences (US), Kaneka Corporation (Japan), NeoVentures Biotechnology Inc. (Canada), Aptus Biotech (Spain), Base Pair Biotechnologies (US), AMSBIO (UK), Novaptech (France), Bio-Techne (US) among others.
DNA Aptamers Industry Dynamics
Drivers: Rising awareness of the advantages of aptamers over antibodies
While antibodies have certain limitations in targeting small molecules, aptamers perform better in targeting small molecules. They can bind to small molecules and dyes and thus be easily used in conventional diagnostic kits, extending their use to point-of-care diagnostics. This, in turn, will ensure a greater market value and increase in acceptance of aptamers in addressing both therapeutic and diagnostic applications. Also, aptamers can bind to large molecules. Nearly 98% of the molecules tend to be proteins, making it easier to discover biomarkers and diagnostic kits.
Restrains: Low market acceptance as compared to antibodies
One of the major drawbacks of aptamers is their low affinity. Even if aptamers can target a wide variety of molecules, studies have shown that they do not have high affinities for all types of molecules. The oligonucleotide structure of aptamers can limit certain interactions between the aptamer and the target molecule. Additionally, aptamers targets are mostly present in blood plasma or cells that are accessible from blood plasma. This leads to their exposure to renal filtration, nuclease degradation, or liver or spleen uptake. Hence, despite their advantages over antibodies, aptamers have low market acceptance and low adoption potential within the scientific society, which results in low market penetration. This is likely to restrain the growth of the market.
Opportunities: Growth in the venture capital funding for research on RNA aptamers
Many aptamer development companies are identifying the potential of aptamers for use in therapeutic and diagnostic applications. These players are now focusing on securing funding from various investors to expand their offerings and strengthen their positions in the market. Therefore, increasing venture capital funding is projected to drive the growth of the market. SomaLogic, Inc. (US), Aptamer Group (UK), and Base Pair Technologies (IS) are striving to expand their capabilities in the market. Investor funding has enabled the companies to achieve their strategic goals.
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Challenges: Shortage of skilled & trained professionals
The development of aptamers and aptamer-based products requires skilled expertise. Also, modified forms of SELEX are needed to apply aptamers for various therapeutic and diagnostic purposes. These processes are highly technical and involve the use of various complex instruments and laboratory documentation systems. All these factors make aptamer development a tedious process and thus limit its uptake among researchers. Highly skilled and trained professionals are needed to carry out modifications; currently, there is a dearth of sufficient workforce in the market. Therefore, the shortage of professionals working in aptamer-related research is projected to restrain the market growth.
The DNA-based aptamers segment will continue to dominate the aptamers market during the forecast period
Based on type, the market is segmented into DNA aptamers, XNA aptamers, and RNA aptamers. The DNA-based aptamers segment dominated the market. The large share of this segment is attributed to their lower production cost and higher stability compared to other nucleic acid-based aptamers and the wide availability of DNA aptamers.
The others segment is estimated to grow at the highest CAGR in the aptamers market, during the forecast period
Based on technology, the market is segmented into SELEX and other technologies. The SELEX technology segment dominated the market. The segment accounts for a large share of the global market as SELEX is one of the most widely used technologies. The other technologies segment is expected to register the highest CAGR during the forecast period due to the increasing focus on developing technologies for aptamer selection.
The therapeutics development segment will continue to dominate the aptamers market during the forecast period
Based on the application, the market is segmented into therapeutics development, research & development, diagnostics, and other applications. The therapeutics development segment dominated the market due to the increasing number of clinical trials evaluating aptamers for new therapies and collaborations among aptamer companies & prominent pharmaceutical and biotechnology firms. The diagnostic segment is projected to grow at the highest CAGR due to the increasing prevalence of chronic diseases and the development of new diagnostic kits to detect cancer and other diseases.
Pharmaceutical & biotechnology companies are the largest end users of aptamers market
Based on end user, the market is segmented into pharmaceutical companies & biotechnology companies, academic & government research institutes, contract research organizations, and other end users. Pharmaceutical & biotechnology companies dominated the market owing to the increasing number of market players offering custom aptamers for use in therapeutics development & rising R&D expenditure. The diagnostic segment will record the highest CAGR during the forecast period due to the development of diagnostic tools for cancer and infectious diseases.
Asia Pacific XNA Aptamers market to witness the highest growth during the forecast period
The global aptamers market is segmented into five major regions North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. In 2020, North America accounted for the largest share of this market. The largest share of North America is attributed to the availability of funds to develop innovative technologies, the presence of prominent market players, and growing collaborations among companies. The Asia Pacific market is estimated to record the highest CAGR during the forecast period. This is attributed to the rising R&D activities on aptamers, the development of aptamer-based products, and the rising focus on drug discovery and development.
Recent Developments
- In August 2021, Aptamer Group, Ltd. and BizCom Japan, Inc. entered into a distribution and marketing agreement to market Optimer discovery and development services in Japan.
- In August 2021, Aptamer Group entered a partnership with ProAxsis Limited. As per the partnership, Aptamer Group will develop validated Optimer ligands against critical targets for ProAxsis’s diagnostic assays
- In July 2021, Aptamer Sciences, Inc. was selected by the Korean government to support a non-clinical project for a new drug development project for COVID-19 treatment and vaccine and will receive a research grant of about USD 0.51 million for one year through this project.
Report Link: ( Aptamers Market )
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