PEST Analysis

Political: The regulations around clinical trials and drug approval get stringent every year. Government agencies focus on patient safety during new drug development.

Economic: Higher R&D spending is required to develop novel targeted therapies. The demand for personalized medicine is increasing which requires biomarker development and The cancer metabolism based therapeutics market has been gaining traction over the past decade owing to its advantages over conventional anticancer therapeutics. Cancer metabolism based therapeutics target the abnormal metabolic pathways of cancer cells to halt tumor growth and progression by interfering with metabolic processes like glycolysis, glutaminolysis, and fatty acid synthesis. They cause less toxicity as compared to conventional chemotherapy and can effectively kill various cancer types.

The global cancer metabolism based therapeutics market is estimated to be valued at US$ 210.2 Bn in 2024 and is expected to exhibit a CAGR of 95% over the forecast period 2023-2030.

Key Takeaways
Key players operating in the cancer metabolism based therapeutics are Calithera Biosciences, Inc., Celgene Corporation, Agios Pharmaceutical, Rafael pharmaceuticals, 3-V Biosciences, and AstraZeneca. Calithera Biosciences, Inc. is a clinical-stage bio pharmaceutical company developing novel small molecule drugs to treat cancer, and expects to bring more products to treat cancer metabolism based on glutaminolysis and others.

The key opportunities in the cancer metabolism based therapeutics lies in the development of more novel and targeted therapies that can disrupt specific cancer metabolism pathways involved in tumor progression and metastasis with minimal side effects. The growing R&D expenditure by pharmaceutical companies and increasing collaborations offer new avenues.

Globally, the cancer metabolism based therapeutics market is expanding mainly driven by the rising incidences of various cancers globally. According to GLOBOCAN 2020, there were around 19.3 million new cancer cases and 10.0 million cancer deaths reported worldwide in 2020. The growth is noticeable in both developed as well as developing economies.

Market Drivers
The rising cancer incidences primarily drive the cancer metabolism based therapeutics market. According to WHO, cancer is the second leading cause of death globally and was responsible for nearly 10 million deaths in 2020. Globally, about 1 in 6 deaths is due to cancer. The growing geriatric population also supports market growth as aging is a primary risk factor for cancer development. In addition, increasing R&D investments by key players and favorable government support in the form of funding and initiatives are accelerating market growth.

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Social: Cancer is one of the leading causes of death. There is an increasing awareness about cancer prevention and risk factors. Early detection helps improve clinical outcomes.

Technological: Advances in omics technologies enabled better understanding of cancer metabolism. Molecular profiling aids the design of drugs inhibiting specific metabolic pathways. Combination therapies are being explored to enhance therapeutic effectiveness.

The North American region holds the major share of the cancer metabolism based therapeutics market currently in terms of value. This can be attributed to high healthcare expenditure, presence of advanced healthcare infrastructure, and large cancer patient pool in the US and Canada.

The Asia Pacific region is poised to be the fastest growing market during the forecast period owing to rising cancer incidence, increasing healthcare spending, expanding research base, and emerging new players. Countries like China and India are investing heavily in development of novel oncology treatments.

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