The antithrombin market is anticipated to grow at a CAGR of approximately 5% during the forecast period. Antithrombin, a protein produced by the liver and present in blood, plays a crucial role in inhibiting blood clotting by inactivating thrombin. Deficiency in antithrombin can arise from conditions such as nephrotic syndrome, liver failure, severe trauma, metastatic tumors, and genetic mutations. Additionally, advancements in drug administration technology and an increase in blood clotting disorders are fueling market growth. Antithrombin deficiency heightens the risk of thromboembolism, which can lead to excessive bleeding during surgeries. Antithrombin III is commonly used for extracorporeal membrane oxygenation (ECMO) during cardiopulmonary bypass. According to the National Institutes of Health (NIH), approximately 310 million surgeries are performed annually in the U.S.

Market Segmentation by Application

The antithrombin market is segmented into therapeutic, research, and diagnostics. In 2020, the therapeutic segment is expected to experience significant growth, driven by the rising number of cardiac surgeries, ongoing drug research and development, and increasing prevalence of heart-related diseases such as atrial fibrillation and heart failure. The demand for antithrombin in therapeutic applications is on the rise, as antithrombic drugs and treatments are crucial for managing heart diseases. For example, the Centers for Disease Control and Prevention (CDC) estimates that 12.1 million people in the U.S. will have atrial fibrillation (AFib) by 2030.

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Market Segmentation by Source

The antithrombin market is categorized into human, goat milk, and others. The goat milk segment is projected to see substantial growth due to its proven medical efficacy. Goat milk is a significant external source of antithrombin, capable of producing as much antithrombin in a year as 90,000 blood donations. Factors such as increasing cases of blood clotting, high blood pressure, high cholesterol, and cardiac surgeries are driving this market segment. Key market players are also launching new products to address antithrombin deficiency.

Market Segmentation by Dosage Form

The market is divided into lyophilized and liquid forms. The lyophilized segment held a significant market share and is expected to grow considerably, primarily due to its use in treating thrombin deficiency and coronary heart diseases (CAD). According to the CDC, around 18.2 million adults have coronary artery disease. Additionally, lyophilized antithrombin is used to treat venous thromboembolism (VTE) and peripheral artery diseases (PAD), serious yet preventable conditions that can cause disability and death. This segment is expected to see continued growth.

Regional Market Analysis

The report provides a comprehensive analysis of major regions, including North America (U.S., Canada, Rest of North America); Europe (Germany, U.K., France, Spain, Italy, Rest of Europe); Asia-Pacific (China, India, Japan, Australia, South Korea, Rest of Asia-Pacific); and the Rest of the World. In 2020, North America held a significant market share, driven by the high prevalence of heart disease, a large population, availability of skilled healthcare professionals, and major pharmaceutical companies. The region also sees a high incidence of blood clots, further contributing to market growth. According to the CDC, as many as 100,000 people in the U.S. die from blood clots each year, costing the nation up to $10 billion annually.

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Major Companies

Key players in the antithrombin market include Grifols S.A., Octapharma AG, LFB USA Inc., CSL Limited, Takeda Pharmaceuticals, Axis-Shield Plc, Siemens AG, Thermo Fisher Scientific, Lee Biosolutions Inc., and BDI Pharma Inc.

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